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  1. Issn: 1751-7176
    Journal: J Clin Hypertens (Greenwich)
    Date: 2019 Sep 18
    Year: 2019
    Ref: J Clin Hypertens (Greenwich). 2019 Sep 18 [Epub ahead of print].
    Abstract: Recently, the 2017 ACC/AHA released new hypertension guidelines and proposed a redefinition of hypertension from 140/90 to 130/80 mm Hg. This study assesses the impact of the lower threshold for hypertension diagnosis on the association of hypertension with target organ damage (TOD). Health checks were conducted in a community-dwelling population in Shanghai in 2017 (N = 10 826; 43.26% mean, age 62 ± 12 years [range 29-95 years]). Subclinical TOD indices were quantified in terms of left ventricular hypertrophy (LVH) by electrocardiogram (Sokolow-Lyon standard), estimated glomerular filtration rate (eGFR), and presence of proteinuria. Information on clinical TOD was obtained by questionnaire. Arteriosclerotic cardiovascular disease (ASCVD) was determined by the 2013 ACC/ AHA recommended guidelines. Compared to the higher threshold (140/90 mm Hg), the lower threshold (130/80 mm Hg) was associated with variable rates of increased detection of hypertension and TOD: (a) Hypertension: incidence of hypertension, 29.5% (51.8%-81.5%) increase in persons with hypertension if the threshold of 130/80 mm Hg is used; (b) Subclinical TOD: LVH, 20.8%; eGFR (30-60 mL/min per 1.73 m2 ), 23.7%; proteinuria, 23.5%; (c) Clinical TOD: chronic kidney disease (CKD) IV (eGFR<30 mL/min per 1.73 m2 ), 3.1%; diabetes (fasting glucose ≥7.0 mmol/L or HbA1C>7.0%), 24.3%; stroke, 26.4%; chronic heart disease, 28.1%; acute myocardial infarction, 19.5% (69.4% to 88.9% of total of 36); ASCVD ≥10%, 29.3%. The lower threshold was associated with a significantly higher detection rate of clinical and subclinical TOD of approximately 20% compared to the higher threshold. 15%-20% of TOD and 29% of ASCVD were also found below the lower threshold of hypertension.
    Authors: Wang Q, Chao H, Zheng S [show all 7]
    Pmid: 31532579
    Mesh: (no MeSH)
  2. Issn: 2044-6055
    Volume: 9
    Issue: 9
    Journal: BMJ Open
    Date: 2019 Sep 17
    Year: 2019
    Ref: BMJ Open. 2019 Sep 17;9(9):e029816.
    Abstract: To explore how health education received by patients with acute coronary syndrome (ACS) and type 2 diabetes mellitus (T2DM) influences patients' self-efficacy and self-management and changes in behaviour at, and following, hospital discharge.
    Authors: Liu XL, Willis K, Wu CJ [show all 6]
    Pages: e029816
    Pmid: 31530604
    Mesh: (no MeSH)
  3. Issn: 1437-1588
    Journal: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
    Date: 2019 Sep 16
    Year: 2019
    Ref: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2019 Sep 16 [Epub ahead of print].
    Abstract: Trends of frequent chronic diseases and health problems, e.g. allergic diseases, have already been published based on the KiGGS Wave 2 study as part of the health monitoring of children and adolescents in Germany. The present work complements these findings with results on less frequent noncommunicable diseases and the trend of communicable, vaccine-preventable diseases.Information from parents about diagnoses and diseases of their 0‑ to 17-year-old children from the representative cross-sectional survey KiGGS Wave 2 (2014-2017) are compared with those from the KiGGS baseline survey (2003-2006) and KiGGS Wave 1 (2009-2012).The current KiGGS results show almost unchanged prevalences for the noncommunicable diseases epilepsy, migraine, and heart disease. However, the data from KiGGS Wave 2 are supportive of an increased prevalence of diabetes mellitus, which nevertheless continues to be relatively rare and predominantly type 1 diabetes in children and adolescents.The decline in measles, chicken pox, and whooping cough diseases related to changes in vaccination recommendations shows that preventive measures can effectively benefit children and adolescents.However, the data on vaccine-preventable diseases indicate regionally varying immunity gaps in certain age groups, so the prevention potential of the vaccination recommendations of the Standing Vaccination Commission (STIKO) at the Robert Koch Institute does not seem to have been sufficiently exploited.
    Authors: Poethko-Müller C, Thamm R, Heidemann C [show all 5]
    Pmid: 31529181
    Mesh: (no MeSH)
  4. Issn: 1881-7823
    Volume: 13
    Issue: 4
    Journal: Biosci Trends
    Date: 2019
    Year: 2019
    Ref: Biosci Trends. 2019;13(4):286.
    Abstract: After decades of research, stem cells have shown tremendous promise to treat a range of diseases, such as heart disease, diabetes, and neurodegenerative disease. However, many challenges remain in their transformation from bench to bedside, such as the potential risk of tumorigenicity from undifferentiated human induced pluripotent stem cells (hiPSC), the lack of large-scale culture systems for clinical treatment, and the inconvenience of cell therapy itself. "Cell sheet technology" and secretome therapy represent advances in these regards. With gradual breakthroughs in theory and technology, stem cell therapy will lead to a new medical revolution in the coming era.
    Authors: Tang W
    Pages: 286
    Pmid: 31527325
    Mesh: (no MeSH)
  5. Issn: 1877-8879
    Journal: Scand J Pain
    Date: 2019 Sep 17
    Year: 2019
    Ref: Scand J Pain. 2019 Sep 17 [Epub ahead of print].
    Abstract: Background and aims In the Western world, it has become clear that we are facing a crisis of overuse, abuse and improperly prescribed use of opioids. As part of the ongoing discussion on opioid use, the use and prescription of tramadol have been addressed in recent years. A significant portion of this discussion should adequately address the risk factors for the use of weak opioid products such as tramadol. The risk factors which characterise the long-term tramadol use are still incompletely understood. Thus, we aimed to describe the characteristics of Danish patients using tramadol in more detail, under different scenarios and determinants of subsequent usage patterns. Methods We conducted a nationwide cohort study to identify individuals purchasing tramadol from 01/01/2004 to 31/12/2015 who are age 16 +  years old by using data from The Danish National Databases; these databases consist of unique information for all citizens in Denmark. Logistic regression analyses were used to assess the potential risk factors for repeated tramadol use. Results The final cancer-free cohort consisted of N = 941,839 tramadol users: 54.4% women, with a mean age of 53.2 years. The number of chronic noncancer pain (CNCP) was 430,641 individuals, and 56% of the total third who repeated the use of tramadol with two +  purchased prescriptions were CNCP patients. The increased risk of repeated use for CNCP was, among others, associated with: male sex (HR 1.21), age 69-110 (HR 1.72), back/spine pain men (HR 1.47), women (HR 1.46), spondylopathies (HR 1.24), male osteoporosis (HR 1.22), multimorbid ulcer/skin (HR 1.28), region of municipality Northern Jutland (HR 1.74), Central Jutland (HR 1.75), number of co-medication 4-9 (HR 1.33), dementia (HR 1.27). Factors associated with decreased risk: co-medication ischemic heart disease (HR 0.85), diagnosis headache (HR 0.70), household income highest tertile (HR 0.81), unknown (HR 0.70), single women (HR 0.96). Conclusions This study proved a widespread prescribed use of tramadol in Denmark, and, as know from the literature, weak opioid use may lead to long-term use of high potent opioids, this usage is inappropriate, in general, but especially for the treatment of CNCP. Implications When striving to reduce the overuse of opioids, focus on the extensive use of tramadol may be essential. The current study indicates an excessive and not appropriately prescribed use of tramadol among Danish CNCP patients. In addition to being inappropriate, such use may also have an impact on the growing problem of an illicit Internet market for this drug. Thus, the situation must be taken seriously. The current study confirms the recent clinical guideline and the National Recommendations in Denmark, which emphasises the risks of problematic use of tramadol. The research may also be relevant in other comparable countries. Caution must especially be taken with CNCP patients with comorbidities like diabetes, lung disease, dementia, and osteoporosis.
    Authors: Hansen CA, Ernst MT, Stougaard M [show all 4]
    Pmid: 31527300
    Mesh: (no MeSH)
  6. Issn: 1841-9038
    Volume: 14
    Issue: 2
    Journal: Maedica (Buchar)
    Date: 2019 Jun
    Year: 2019
    Ref: Maedica (Buchar). 2019 Jun;14(2):86-92.
    Abstract: Introduction:Chronic obstructive pulmonary disease (COPD) is a global health problem resulting in significant morbidity. Acute exacerbation of COPD (AECOPD) is a severe complication associated with increased short- and long-term mortality. Identifying predictors of long-term mortality after a severe AECOPD may improve management and long-term outcome of this disease. Materials and methods:A two-year prospective cohort study was undertaken in an academical medical center between 2016 and 2018. Patients with severe AECOPD who required non-invasive ventilation (NIV) were included. Baseline characteristics at inclusion, comorbidities (kidney dysfunction, left heart disease, diabetes), number of prior episodes of AECOPD and indication for long-term oxygen therapy (LTOT) or non-invasive ventilation (LTNIV) were recorded. Patients were monitored for a two-year period after initial admission. Outcomes were six-month, one-year and two-year mortality, irrespective of cause. Outcomes:51 patients (31 male, mean age 68.1) were included in the study. Mortality rates at six months, one year and two years were 20, 26 and 36%, respectively. Patients receiving LTOT and LTNIV at discharge had lower mortality at two years versus patients with no indication for LTOT and LTNIV at discharge. Absence of LTOT increased six-month mortality (OR .2, 95% CI, .04 to .90) and one-year mortality (p<.05). FEV1 and BMI were also correlated with long-term mortality in univariate analysis, p<.05. Age, number of prior episodes of AECOPD or the presence of comorbidities had no influence on long-term mortality. Conclusion:After an episode of severe AECOPD, LTOT is associated with lower long-term mortality when compared to patients with no severe hypoxemia at discharge. A decreased lung function and body mass index increase long-term mortality.
    Authors: Steriade AT, Davidoiu A, Afrasinei A [show all 8]
    Pages: 86-92
    Pmid: 31523286
    Mesh: (no MeSH)
  7. Issn: 1942-0080
    Volume: 12
    Issue: 9
    Journal: Circ Cardiovasc Imaging
    Date: 2019 Sep
    Year: 2019
    Ref: Circ Cardiovasc Imaging. 2019 Sep;12(9):e009476.
    Abstract: Diabetes mellitus (DM) is associated with increased risk of cardiovascular disease. Detection of early cardiac changes before manifest disease develops is important. We investigated early alterations in cardiac structure and function associated with DM using cardiovascular magnetic resonance imaging.
    Authors: Jensen MT, Fung K, Aung N [show all 18]
    Pages: e009476
    Pmid: 31522551
    Mesh: (no MeSH)
  8. Issn: 1386-9620
    Journal: Health Care Manag Sci
    Date: 2019 Sep 14
    Year: 2019
    Ref: Health Care Manag Sci. 2019 Sep 14 [Epub ahead of print].
    Abstract: In recent years, with the increasing aging of society, the number of patients with chronic heart disease, hypertension and diabetes has increased dramatically. It has guiding significance for the prevention and treatment by long-term monitoring of the physiological signs of patients with chronic diseases, scoring statistical data, and predicting the development trend of users' health. The work used the data collected by WIT120 system to analyze the pre-processed thick data based on adaptive k-means clustering method under the MapReduce framework, and the GM (1,1) grey model was used to predict the future health status of users. The simulation results have verified the effectiveness of the proposed algorithm.
    Authors: Zhou Q, Zhang Z, Wang Y
    Pmid: 31522301
    Mesh: (no MeSH)
  9. Issn: 1878-8769
    Journal: World Neurosurg
    Date: 2019 Sep 12
    Year: 2019
    Ref: World Neurosurg. 2019 Sep 12 [Epub ahead of print].
    Abstract: There has been no precise guide for treatment management of aneurysmal subarachnoid hemorrhage (aSAH) based on the patient's age and treatment method. This study clarifies each risk management for aSAH according to age and treatment method listed in a nationwide database.
    Authors: Ikawa F, Michihata N, Iihara K [show all 8]
    Pmid: 31521760
    Mesh: (no MeSH)
  10. Issn: 1433-8726
    Journal: World Journal of Urology
    Date: 2019 Sep 13
    Year: 2019
    Ref: World Journal of Urology. 2019 Sep 13 [Epub ahead of print].
    Abstract: Co-morbidities may induce local and systemic tumor progression of renal cell carcinoma (RCC); however, the prognostic impact of co-morbidities has not yet been well characterized.
    Authors: Heide J, Ribback S, Klatte T [show all 10]
    Pmid: 31520111
    Mesh: (no MeSH)
  11. Issn: 1742-481X
    Journal: Int Wound J
    Date: 2019 Sep 13
    Year: 2019
    Ref: Int Wound J. 2019 Sep 13 [Epub ahead of print].
    Abstract: Laser Doppler velocimetry estimates tissue perfusion providing a record of microvascular blood flow. Patients with heart disease or diabetes mellitus have impaired microvascular perfusion leading to impaired wound healing. Aged garlic extract (AGE) has a positive effect on vascular elasticity. This study aimed to assess the effect of long-term treatment with AGE on cutaneous tissue perfusion. A total of 122 patients with Framingham Risk Score ≥ 10 were randomised in a double-blinded manner to placebo or 2400 mg AGE daily for 1 year and monitored. Cutaneous microcirculation was measured at 0 and 12 months using laser Doppler velocimetry. A repeated measures analysis of variance (ANOVA) with a Greenhouse-Geisser correction determined that mean post-occlusive reactive hyperaemia differed significantly between time points. The mean percent change between the two time points 0 and 12 months was 102, 64 (174, 15)% change for AGE and 78, 62 (107, 92)% change for the placebo group (F[1, 120] = 5. 95, P < 0.016), 12 months of AGE increases the microcirculation in patients with an increased risk for cardiovascular events estimated using the Framingham risk score. Increased microcirculation could hypothetically facilitate wound healing.
    Authors: Wlosinska M, Nilsson AC, Hlebowicz J [show all 6]
    Pmid: 31518044
    Mesh: (no MeSH)
  12. Issn: 1945-7170
    Journal: Endocrinology
    Date: 2019 Sep 12
    Year: 2019
    Ref: Endocrinology. 2019 Sep 12 [Epub ahead of print].
    Abstract: The increasing occurrence of obesity has become a significant public health concern. Obese individuals have higher prevalence of heart disease, stroke, osteoarthritis, diabetes, and reproductive disorders. Reproductive problems include menstrual irregularities, pregnancy complications, and infertility due to anovulation, in women, and lower testosterone and diminished sperm count, in men. In particular, obese women have reduced levels of both gonadotropin hormones and, in obese men, lower testosterone is accompanied by diminished luteinizing hormone. Together these findings indicate central dysregulation of the hypothalamus-pituitary-gonadal axis, specifically at the level of the GnRH neuron function, which is the final brain output for the regulation of reproduction. Obesity is a state of hyperinsulinemia, hyperlipidemia, hyperleptinemia, and chronic inflammation. Herein, we review recent advances in our understanding of how these metabolic and immune changes affect hypothalamic function and regulation of GnRH neuron. In the latter part, we focus on neuroinflammation as a major consequence of obesity, and discuss findings that reveal that GnRH neurons are uniquely positioned to respond to inflammatory changes.
    Authors: Lainez NM, Coss D
    Pmid: 31513269
    Mesh: (no MeSH)
  13. Issn: 1530-0374
    Journal: Menopause
    Date: 2019 Sep 09
    Year: 2019
    Ref: Menopause. 2019 Sep 09 [Epub ahead of print].
    Abstract: Statins are a class of drugs that competitively bind to the active site of HMG-CoA reductase enzyme, thereby inhibiting the initial steps in cholesterol synthesis. Originally approved for use in lowering serum cholesterol, a risk factor for developing atherosclerosis and coronary heart disease, statins have subsequently been noted to have myriad extrahepatic effects, including potential effects on cognition, diabetes, breast cancer, bone, and muscle. This narrative review assesses the current state of the science regarding the risks and benefits of statin therapy in women to identify areas where additional research is needed.
    Authors: Faubion SS, Kapoor E, Moyer AM [show all 5]
    Pmid: 31513091
    Mesh: (no MeSH)
  14. Issn: 1561-9125
    Volume: 32
    Issue: 3
    Journal: Adv Gerontol
    Date: 2019
    Year: 2019
    Ref: Adv Gerontol. 2019;32(3):422-430.
    Abstract: We used quantitative real-time PCR method to analyse mtDNA copy number in a random subsample (n=996; 358 men aged 66,31±7,24 years; 468 women aged 67,62±7,1 years) selected from a population cohort (n=9 630) examined at baseline in international project HAPIEE in Novosibirsk, Russia, in 2003-2005. The participants were re-examined after 12 years in 2015-2017. The average relative number of mtDNA copies in peripheral blood leukocytes was greater in women than in men, independently of age and smoking (p=0,001). mtDNA copy number was inversely correlated with age both in men (p=0,005) and women (p<0,001). In age adjusted analysis, mtDNA copy number was inversely associated with waist, hip and heart rate in both sexes. In addition, mtDNA copy number in women was inversely associated with triglycerides and glucose, aterogenity index and positively with HDL cholesterol. In men, mtDNA copy number was positively associated with physical activity. The age-adjusted mean of mtDNA copy number among male never-smokers was greater than in smokers (p=0,003), and the mean mtDNA copy number was lower in women with diabetes than in women without diabetes (p=0,005). In both sexes, subjects with baseline history of hypertension had lower mtDNA copy number after 12-year follow-up than those without hypertension (p=0,05). This broadly supports the hypothesis that mtDNA copy number may act as biomarker of ageing.
    Authors: Maximov VN, Malyutina SK, Orlov PS [show all 10]
    Pages: 422-430
    Pmid: 31512430
    Mesh: (no MeSH)
  15. Issn: 2047-2927
    Journal: Andrology
    Date: 2019 Sep 12
    Year: 2019
    Ref: Andrology. 2019 Sep 12 [Epub ahead of print].
    Abstract: The aim of the study was to investigate the ability of the systemic inflammatory parameters to predict the discrimination of the phases of Peyronie's disease (PD).
    Authors: Özbir S, Değirmentepe RB, Atalay HA [show all 7]
    Pmid: 31512411
    Mesh: (no MeSH)
  16. Issn: 2045-2322
    Volume: 9
    Issue: 1
    Journal: Sci Rep
    Date: 2019 Sep 11
    Year: 2019
    Ref: Sci Rep. 2019 Sep 11;9(1):13156.
    Abstract: Prevalence estimates and evidence informing treatment targets for thyroid dysfunction largely come from studies of middle-aged adults. We conducted a cross-sectional analysis to determine the prevalence of thyroid dysfunction and risk factors for abnormal thyroid tests in participants aged ≥65 in the Atherosclerosis Risk in Communities (ARIC) study (N = 5,392). We measured serum concentrations of triiodothyronine (T3), free thyroxine (FT4), thyroid peroxidase antibody (Anti-TPO), and thyroid stimulating hormone (TSH). In this population (58% women, 22% black), 17% reported medication use for thyroid dysfunction. Among those not on treatment, the prevalence of overt and subclinical hypothyroidism was 0.82% and 6.06%, respectively. Overt and subclinical hyperthyroidism affected 0.26% and 0.78%, respectively. Multivariable adjusted TSH, FT4 and T3 levels were 25%, 1.3% and 3.9% lower in blacks compared to whites, respectively. Men were less likely to be anti-TPO positive compared to women (p < 0.001). Former and never smoking were associated with lower T3 and FT4 levels compared to current smoking. The prevalence of thyroid dysfunction in older adults is nearly 25%. Multiple illnesses can interact to contribute to declines in health. Additional attention to thyroid dysfunction and screening in this age group is recommended.
    Authors: Diab N, Daya NR, Juraschek SP [show all 8]
    Pages: 13156
    Pmid: 31511587
    Mesh: (no MeSH)
  17. Issn: 2044-6055
    Volume: 9
    Issue: 9
    Journal: BMJ Open
    Date: 2019 Sep 11
    Year: 2019
    Ref: BMJ Open. 2019 Sep 11;9(9):e028653.
    Abstract: This study protocol outlines our planned systematic review and dose-response meta-analysis of postdiagnosis physical activity and mortality in people with non-communicable diseases (NCDs).
    Authors: Geidl W, Schlesinger S, Mino E [show all 8]
    Pages: e028653
    Pmid: 31511283
    Mesh: (no MeSH)
  18. Issn: 1941-7705
    Volume: 12
    Issue: 9
    Journal: Circ Cardiovasc Qual Outcomes
    Date: 2019 Sep
    Year: 2019
    Ref: Circ Cardiovasc Qual Outcomes. 2019 Sep;12(9):e005879.
    Abstract: Patients on dialysis who have an acute myocardial infarction (AMI) have an exceedingly poor prognosis, but it is unknown to what extent guideline-recommended interventions and treatments are used and to which benefit. We aimed to assess temporal changes in the use of treatments and survival rates in dialysis patients with an AMI.
    Authors: Szummer K, Lindhagen L, Evans M [show all 8]
    Pages: e005879
    Pmid: 31510770
    Mesh: (no MeSH)
  19. Issn: 1879-1484
    Volume: 289
    Journal: Atherosclerosis
    Date: 2019 Aug 31
    Year: 2019
    Ref: Atherosclerosis. 2019 Aug 31;289:126-131. [Epub ahead of print].
    Abstract: Acute myocardial infarction (AMI) is associated with high mortality globally and remains a public health burden. We sought to investigate the relation between the American Heart Association's cardiovascular health metrics (CVH) and the risk of AMI among middle-aged Finnish men.
    Authors: Isiozor NM, Kunutsor SK, Voutilainen A [show all 6]
    Pages: 126-131
    Pmid: 31509777
    Mesh: (no MeSH)
  20. Issn: 1464-5491
    Journal: Diabetic Medicine
    Date: 2019 Sep 10
    Year: 2019
    Ref: Diabetic Medicine. 2019 Sep 10 [Epub ahead of print].
    Abstract: The Microalbuminuria Education Medication and Optimisation (MEMO) study, revealed improved cardiovascular risk and glycaemic control with 18 months of intensive multifactorial intervention in high-risk people with type 2 diabetes, without any increase in severe hypoglycaemia. Our aim was to assess longer-term outcomes at 4-year follow-up in these participants.
    Authors: Crasto W, Morrison AE, Gray LJ [show all 11]
    Pmid: 31505051
    Mesh: (no MeSH)
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